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Indomethacin
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blocks the enzymes that make prostaglandins (cyclooxygenase 1 and
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2) and thereby reduces the levels of prostaglandins. Indomethacin and other NSAIDs may decrease the elimination of lithium overdose prescription drugs (Eskalith, Lithobid) by the kidneys and, therefore, increase the blood
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level of lithium, which could lead to lithium toxicity. Indomethacin may cause or worsen stomach or intestinal bleeding or ulcers. As a result, fever, pain and inflammation best drug store shampoo are reduced. Indomethacin should be taken with food in order to reduce
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abdominal
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discomfort.
The impairment is most likely to occur in patients with preexisting impairment of kidney function or congestive heart failure, and use of NSAIDs in these patients should be done cautiously. Oral suspension and suppositories should be kept below 30 C (86 F). Fluid retention, blood clots, heart attacks, hypertension (high blood pressure), and heart failure have
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also been associated with the use of NSAIDs.. Indomethacin is excreted in breast milk and therefore should be avoided by nursing mothers. It is similar
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to ibuprofen (Motrin) and naproxen
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(Naprosyn, Aleve). 25 and 50 mg; Capsules, sustained release. Indomethacin is available in a sustained (slow) release form (Indocin-SR). The FDA first approved indomethacin in January 1965.
Indomethacin works by reducing the production of prostaglandins. Sometimes, ulceration and bleeding can occur without abdominal pain, and black tarry stools, weakness, and dizziness
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upon standing (orthostatic hypotension) may be the only signs of a ulceration. Use during pregnancy has not been
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adequately studied.
Prostaglandins are chemicals that the body produces to cause fever and pain that are associated with inflammation. Indomethacin may cause
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ulceration of the stomach or intestine, and the ulcers may bleed. The most com side effects are nausea, vomiting, diarrhea,
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stomach discomfort, heartburn, rash, headache, dizziness and drowsiness. It may lead to perforation of the intestine. When indomethacin is used in combination with aminoglycoside antibiotics (for example, gentamicin) the blood levels of the aminoglycoside may increase, presumably because the elimination of aminoglycoside from the body is reduced. NSAIDs reduce the ability of blood to clot and therefore increase bleeding after an injury. Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that reduces fever, pain and inflammation. Indomethacin may reduce the blood pressure-lowering
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effects of drugs that are given to reduce blood pressure.
This may occur because prostaglandins play a role in the regulation of blood pressure. Cholestyramine (Questran) and colestipol (Colestid) may decrease the absorption of indomethacin by binding to indomethacin in the intestine and preventing absorption into the body. Indomethacin is used for the treatment of inflammation caused
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by rheumatoid arthritis, ankylosing spondylitis, gouty arthritis, osteoarthritis, and soft tissue injuries such as tendinitis and bursitis. Individuals taking oral blood thinners or anticoagulants [for example, warfarin (Coumadin)] should avoid indomethacin because indomethacin also thins the blood, and excessive blood thinning may lead to bleeding. Individuals who have nasal polyps or are allergic to aspirin or other NSAIDs should not use
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indomethacin because there is an increased risk of severe allergic reactions in these individuals. Indomethacin may have adverse effects on the fetus. NSAIDs reduce the flow of blood to the kidneys and impair function of the kidneys.
Capsules should be kept at room temperature 15-30 C (59-86 F). This may lead to aminoglycoside-related side effects. The oral suspension should not be frozen. The recommended dose for adults is 50-200 mg per day split into 2-3 doses.
